Division of Medical Informatics and Bioinformatics,
Kobe University Hospital / Graduate School of Medicine

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Research Achievement
 
 
  2016
  1. Hiromi Ohtsubo, Taro Okada, Kandai Nozu, Yutaka Takaoka, Akemi Shono, Katsuhiko Asanuma, Lifang Zhang, Xue Jun Fu, Koichi Nakanishi, Mariko Taniguchi-Ikeda, Hiroshi Kaito, Kazumoto Iijima, Shun-ichi Nakamura: Identification of mutations in FN1 leading to glomerulopathy with fibronectin deposits. Pediatric Nephrology doi:10.1007/s00467-016-3368-7, 2016
  2. Masahito Ogasawara, Yutaka Nakamura, Naoto Morikawa, Hiroto Nitanai, Satoshi Moriguchi, Ryosuke Chiba, Heisuke Saito, Mika Ohta, Tatsuo Tanita, Tamotsu Sugai, Kazutaka Maeyama, Kohei Yamauchi, Yutaka Takaoka: Analysis of a single codon E746 deletion in exon 19 of the epidermal growth factor receptor. Cancer Chemotherapy and Pharmacology 77(5), 1019-1029, 2016
  3. Mika Ohta, Tsuyoshi Oda, Shinichi Kita, Eiichi Maeda, Aki Sugano, Yutaka Takaoka: Research and development of braille e-learning program for the visually impaired and its learning effect. Bulletin of Kobe Tokiwa University 9, 35-40, 2016
  4. Aki Sugano, Tsuyoshi Oda, Mika Ohta, Minoru Kumaoka, Shinichi Kita, Tetsuya Watanabe, Akihiko Ichinose, Yumiko Takao, Eiichi Maeda, Takashi Nishimoto, Yutaka Takaoka: Effectiveness of ontology-based learning material of acupuncture and moxibustion for visually impaired. Bulletin of Kobe Tokiwa University 9, 23-34, 2016
2015
  1. Yumiko Takao, Yutaka Takaoka, Aki Sugano, Hitoaki Sato, Yasushi Motoyama, Mika Ohta, Takashi Nishimoto, Satoshi Mizobuchi: Shakuyaku-kanzo-to (Shao-Yao-Gan-Cao-Tang) as treatment of painful muscle cramps in patients with lumbar spinal stenosis and its minimum effective dose. Kobe J Med Sci 61(5), E132-E137, 2015
  2. Hirotaka Sato, Yutaka Takaoka: RUNX2 expression during early healing of tooth-extraction wounds in rats. Journal of Oral Science 57(4), 319-325. 2015
  3. Yanshuang Mu, Shoude Jin, Jingling Shen, Aki Sugano, Yutaka Takaoka, Lixia Qiang, Bruno P Imbimbo, Ken-ichi Yamamura, Zhenghua Li: CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci. FEBS Letters 589(7), 849-856, 2015
2014
  1. Eiji Nakano, Ryusuke Ono, Taro Masaki, Seiji Takeuchi, Yutaka Takaoka, Eiichi Maeda, Chikako Nishigori: Differences in Clinical Phenotype among Patients with XP Complementation Group D: 3D Structure and ATP-Docking of XPD In Silico. Journal of Investigative Dermatology 134(6), 1775-1778, 2014
2013
  1. Naoko Yasui, Yutaka Takaoka, Hisahide Nishio, Dian K. Nurputra, Kenji Sekiguchi, Hirotoshi Hamaguchi, Hisatomo Kowa, Eiichi Maeda, Aki Sugano, Kenji Miura, Toshiyuki Sakaeda, Fumio Kanda, Tatsushi Toda: Molecular pathology of Sandhoff disease with p.Arg505Gln in HEXB: application of simulation analysis. Journal of Human Genetics 58, 611-617, 2013
  2. Tsuyoshi Oda, Aki Sugano, Masashi Shimbo, Kenji Miura, Mika Ohta, Masako Matsuura, Mineko Ikegami, Tetsuya Watanabe, Shinichi Kita, Akihiro Ichinose, Eiichi Maeda, Yuji Matsumoto, Yutaka Takaoka: Improvement in Accuracy of Word Segmentation of a Web-Based Japanese-to-Braille Translation Program for Medical Information. Journal of Communication and Computer 10(1), 82-89, 2013
  3. Yoichiroh Hosokawa, Mika Ohta, Akihiko Ito, Yutaka Takaoka: Photomechanical ablation of biological tissue induced by focused femtosecond laser and its application for acupuncture. Applied Physics A 110, 613-616, 2013
  4. Yutaka Takaoka, Mika Ohta, Aki Sugano, Akihiko Ito, Yoichiroh Hosokawa: New Technology: Femtosecond laser may be used for future Acupuncture therapy, Acupuncture in Modern Medicine (Lucy L. Chen and Tsung O. Cheng), InTech Publishers, Croatia, 221-231, 2013
2012
  1. Kazuya Ishibashi, Ken Watanabe, Yutaka Takaoka, Tetsuya Watanabe, Shinichi Kita: Prevalence effect in haptic search. i-Perception 3(8), 495-498, 2012
  2. Masaki Ohmuraya, Aki Sugano, Masahiko Hirota, Yutaka Takaoka, Ken-ichi Yamamura: Role of intrapancreatic SPINK1/Spink3 expression in the development of pancreatitis.(review) Frontiers in Physiology 3:126, doi:10.3389/fphys.2012.00126, 2012
  3. Dian K. Nurputra, Taku Nakagawa, Yasuhiro Takeshima, Indra S.K. Harahap, Satoru Morikawa, Toshiyuki Sakaeda, Poh San Lai, Masafumi Matsuo, Yutaka Takaoka, Hisahide Nishio: Paramyotonia congenita: from clinical diagnosis to in silico protein modeling analysis. Pediatrics International 54, 602-612, 2012
  4. Rusdy Ghazali Malueka, Yutaka Takaoka, Mariko Yagi, Hiroyuki Awano, Tomoko Lee, Ery Kus Dwianingsih, Atsushi Nishida, Yasuhiro Takeshima, Masafumi Matsuo: Categorization of 77 dystrophin exons into 5 groups by a decision tree using indexes of splicing regulatory factors as decision markers. BMC Genetics 13(23), doi:10.1186/1471-2156-13-23, 2012
  5. Yusuke Nagara, Man Hagiyama, Naoya Hatano, Eugene Futai, Satoshi Suo, Yutaka Takaoka, Yoshinori Murakami, Shoichi Ishiura, Akihiko Ito: Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by A disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by gamma-secretase complex. Biochemical and Biophysical Research Communications 417(1), 462-467, 2012
2011
  1. Naoki Arizono, Minoru Yamada, Tatsuya Tegoshi, Yutaka Takaoka, Mika Ohta, Toshiyuki Sakaeda: Hsp12.6 Expression is Inducible by Host Immunity in Adult Worms of the Parasitic Nematode Nippostrongylus brasiliensis. PLoS ONE 6(3):e18141., doi:10.1371/journal.pone.0018141, 2011
  2. Mika Ohta, Aki Sugano, Shuji Goto, Surini Yusoff, Yushi Hirota, Kotaro Funakoshi, Kenji Miura, Eiichi Maeda, Nobuo Takaoka, Nobuko Sato, Hiroshi Ishizuka, Naoki Arizono, Hisahide Nishio, Yutaka Takaoka: Full-length sequence of mouse acupuncture-induced 1-L (Aig1l) gene including its transcriptional start site. Evidence-based Complementary and Alternative Medicine doi:10.1093/ecam/nep121, 2011
  3. Indra Sari Kusuma Harahap, Naoko Sasaki, Gunadi, Surini Yusoff, Myeong Jin Lee, Satoru Morikawa, Noriyuki Nishimura, Tomohiro Sasaki, Seiichiro Usuki, Midori Hirai, Mika Ohta, Yutaka Takaoka, Takashi Nishimoto, Hisahide Nishio: Herbal medicine containing licorice may be contraindicated for a patient with an HSD11B2 mutation. Evidence-based Complementary and Alternative Medicine doi:10.1093/ecam/nep211, 2011
  4. Yutaka Takaoka, Mika Ohta, Aki Sugano: Molecular Evidence:EA may inhibit the Muscle Atrophy, Acupuncture - Clinical Practice, Particular Techniques and Special Issues (Marcelo Saad), InTech Publishers, Croatia, 43-58, 2011
2010
  1. Aki Sugano, Mika Ohta, Tsuyoshi Oda, Kenji Miura, Shuji Goto, Masako Matsuura, Eiichi Maeda, Toshiko Ohshima, Yuji Matsumoto, Yutaka Takaoka: eBraille: A web based translation program for Japanese text to Braille. Internet Research 20(5), 582-592, 2010
  2. Yutaka Takaoka, Mika Ohta, Atsuko Takeuchi, Kenji Miura, Masafumi Matsuo, Toshiyuki Sakaeda, Aki Sugano, Hisahide Nishio: Ligand orientation governs conjugation capacity of UDP-glucuronosyltransferase 1A1, Journal of Biochemistry 148(1), 25-28, 2010
  3. Surini Yusoff, Atsuko Takeuchi, Chitose Ashi, Masako Tsukada, Nur Hasnah Ma'Amor, Bin Alwi Zilfalil, Narazah Mohd Yusoff, Tsutomu Nakamura, Midori Hirai, Indra Sari Kusuma Harahap, Gunadi, Myeong Jin Lee, Noriyuki Nishimura, Yutaka Takaoka, Satoru Morikawa, Ichiro Morioka, Naoki Yokoyama, Masafumi Matsuo, Hisahide Nishio, Hans van Rostenberghe: A polymorphic mutation, c.-3279T>G, in the UGT1A1 promoter is a risk factor for neonatal jaundice in the Malay population. Pediatric Research 67(4), 401-406, 2010
  4. Naoto Tadano, Cheng-Kun Du, Fumiaki Yumoto, Sachio Morimoto, Mika Ohta, Ming-Fang Xie, Koji Nagata, Dong-Yun Zhan, Qun-Wei Lu, Yoshikazu Miwa, Fumi Takahashi-Yanaga, Masaru Tanokura, Iwao Ohtsuki, Toshiyuki Sasaguri: Biological actions of green tea catechins on cardiac troponin C. British Journal of Pharmacology 161(5), 1034-1043, 2010
2009
  1. Gunadi, Kenji Miura, Mika Ohta, Aki Sugano, Myeong Jin Lee, Yumi Sato, Akiko Matsunaga, Kazuhiro Hayashi, Tatsuya Horikawa, Kazunori Miki, Mari Wataya-Kaneda, Ichiro Katayama, Chikako Nishigori, Masafumi Matsuo, Yutaka Takaoka, Hisahide Nishio: Two novel mutations in the ED1 gene in Japanese families with X-linked hypohidrotic ectodermal dysplasia. Pediatric Research 65(4), 453-457, 2009
2008
  1. Seiya Inoue, Mika Ohta, Zhenghua Li, Gang Zhao, Yutaka Takaoka, Naomi Sakashita, Kazuhisa Miyakawa, Koji Takada, Hajime Tei, Misao Suzuki, Michio Masuoka, Yoshiyuki Sakaki, Kiyoshi Takahashi, Ken-Ichi Yamamura: Specific pathogen free conditions prevent transthyretin amyloidosis in mouse models. Transgenic Research 17(5), 817-826, 2008
  2. Kiyomasa Nishii, Sachio Morimoto, Reiko Minakami, Yumi Miyano, Kanako Hashizume, Mika Ohta, Dong-Yun Zhan, Qun-Wei Lu, Yosaburo Shibata: Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo. Developmental Biology 322(1), 65-73, 2008
  3. Yutaka Takaoka: Treatment of Muscle Pain by Japanese traditional medicine (Acupuncture and Kampo). Pain Management: New Research, Nova Science Publishers, NY, 89-97, 2008
2007
  1. Yutaka Takaoka, Mika Ohta, Akihiko Ito, Kunihiko Takamatsu, Aki Sugano, Kotaro Funakoshi, Nobuo Takaoka, Nobuko Sato, Hiroshi Yokozaki, Naoki Arizono, Shuji Goto, Eiichi Maeda: Electroacupuncture Suppresses Myostatin Gene Expression: Cell Proliferative Reaction in Mouse Skeletal Muscle. Physiological Genomics 30(2), 102-110, 2007
  2. Cheng-Kun Du, Sachio Morimoto, Kiyomasa Nishii, Reiko Minakami, Mika Ohta, Naoto Tadano, Qun-Wei Lu, Yuan-Yuan Wang, Dong-Yun Zhan, Misato Mochizuki, Satomi Kita, Yoshikazu Miwa, Fumi Takahashi-Yanaga, Takahiro Iwamoto, Iwao Ohtsuki, Toshiyuki Sasaguri: Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation. Circulation Research 101(2), 185-194, 2007
2004
  1. Yutaka Takaoka, Mika Ohta, Kazuhisa Miyakawa, Osamu Nakamura, Misao Suzuki, Kiyoshi Takahashi, Ken-ichi Yamamura, Yoshiyuki Sakaki: Cysteine 10 is a Key Residue in Amyloidogenesis of Human Transthyretin Val30Met. American Journal of Pathology 164(1), 337-345, 2004
  2. Setsuko Ii, Mika Ohta, Eiji Kudo, Takashi Yamaoka, Tomokazu Tachikawa, Maki Moritani, Mitsuo Itakura, Katsuhiko Yoshimoto: Redox State-Dependent and Sorbitol Accumulation-Independent Diabetic Albuminuria in Mice with Transgene-Derived Human Aldose Reductase and Sorbitol Dehydrogenase Deficiency. Diabetologia 47(3), 541-548, 2004
2002
  1. Hiromitsu Noguchi, Mika Ohta, Shoji Wakasugi, Kazuhiro Noguchi, Naoko Nakamura, Osamu Nakamura, Kazuhisa Miyakawa, Motohiro Takeya, Misao Suzuki, Naomi Nakagata, Toru Urano, Tomomichi Ono, Ken-ichi Yamamura: Effect of the intestinal flora on amyloid deposition in a transgenic mouse model of familial amyloidotic polyneuropathy. Experimental Animals 51(4), 309-316, 2002
  2. Sachio Morimoto, Qun-Wei Lu, Keita Harada, Fumi Takahashi-Yanaga, Reiko Minakami, Mika Ohta, Toshiyuki Sasaguri, Iwao Ohtsuki: Ca2+-desensitizing effect of a deletion mutation ΔK210 in cardiac troponin T that causes familial dilated cardiomyopathy. Proceedings of National Academy of Science USA 99(2), 913-918, 2002
2001
  1. Fumi Takahashi-Yanaga, Sachio Morimoto, Keita Harada, Reiko Minakami, Fumie Shiraishi, Mika Ohta, Qun-Wei Lu, Toshiyuki Sasaguri, Iwao Ohtsuki: Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology 33(12), 2095-2017, 2001
  2. Sachio Morimoto, Mika Ohta, Takako Goto, Iwao Ohtsuki: A pH-sensitive interaction of troponin I with troponin C coupled with strongly binding cross-bridges in cardiac myofilament activation. Biochemical and Biophysical Research Communications 282(3), 811-815, 2001
1999
  1. Mika Ohta, Makoto Nitta, Masaru Yamaizumi: High sensitivity of the ultraviolet-induced p53 response in ultraviolet-sensitive syndrome, a photosensitive disorder with a putative defect in deoxyribonucleic acid repair of actively transcribed genes. Mutation Research 433(1), 23-32, 1999
  2. Yutaka Takaoka, Mika Ohta, Kazuhisa Miyakawa, Hirofumi Shimada, Osamu Nakamura, Misao Suzuki, Kiyoshi Takahashi, Ken-ichi Yamamura, Yoshiyuki Sakaki: Cys10 residue may be a key factor for Met30 TTR amyloidogenesis in type I familial amyloidotic polyneuropathy. AMYLOID and AMYLOIDOSIS (Morie A. Gertz), Parthenon Publishing, Norton, UK, 246-248, 1999
1997
  1. Yutaka Takaoka, Fumi Tashiro, Shigehiro Yi, Shuichiro Maeda, Kazunori Shimada, Kiyoshi Takahashi,Yoshiyuki Sakaki, Ken-ichi Yamamura: Comparison of amyloid deposition in two lines of transgenic mouse that model familial amyloidotic polyneuropathy, type I. Transgenic Research 6(4), 261-269, 1997
1996
  1. Akio Hiura, Fumio Nasu, Hiroshi Ishizuka, Mishiyo Kuwahara, Mika Ohta: Evidence of synaptic contacts of nociceptive primary afferent central terminals on GABAergic interneurons in the substantia gelatinosa. Archives of Histology and Cytology 59(1), 55-60, 1996
  2. Katsuhiko Yoshimoto, Rie Murakami, Maki Moritani, Mika Ohta, Hiroyuki Iwahana, Hiromitsu Namauchi, Mistuo Itakura: Loss of ganciclovir sensitivity by exclusion of thymidine kinase gene from transplanted proinsulin-producing fibroblasts as a gene therapy model for diabetes. Gene Therapy 3(3), 230-234, 1996
  3. Mitsuo Itakura, Setsuko Ii, Mika Ohta, Takashi Yamaoka: Polyol accumulation versus diabetic retinopathy and nephropathy in transgenic mice expressing human aldose reductase. Lessons from animal diabetes VI (E. Shafrir), Birkhäuser, Boston, USA, 175-200, 1996
1995
  1. Akio Hiura, Hiroshi Ishizuka, Mika Ohta. Fluoride-resistant acid phosphatase(FRAP)-positive primary afferent central terminals in the mouse substantia gelatinosa: Acta Histochemica et Cytochemica 28(6), 501-505, 1995
  2. Mika Ohta, Setsuko Ii, Takashi Yamaoka, Kazuo Ono, Yasuo Kokai, Jun-ichiro Fujimoto, Hiroyuki Iwahana, Katsuhiko Yoshimoto, Mitsuo Itakura: Galactose-induced albuminuria in transgenic mice expressing human aldose reductase. Nutrition Research 15(9), 1343-1353, 1995
1994
  1. Yutaka Takaoka, Hiroshi Ideguchi, Miho Matsuda, Norihiro Sakamoto, Takayuki Takeuchi, Yasuyuki Fukumaki: A novel mutation in the erythrocyte protein 4.2 gene of Japanese patients with hereditary spherocytosis (protein 4.2 Fukuoka). British Journal of Haematology 88(3), 527-533, 1994
 
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